Born in Rome in 1949, Rabbi Di Segni practiced the profession of medical doctor (radiologist, head of department of a large Roman public hospital) for many years associating it with rabbinic activities. He obtained the semikha at the Italian Rabbinical College in 1973, where he continued to teach and which he has directed since 1999. In addition to teaching, he is active in research, publishing numerous philological studies and books on various aspects of Judaism; involved in diffusion of traditional Jewish culture, in papers and digital media. President of the project of Italian translation of the Babylonian Talmud (6 treatises up now published). Chief Rabbi of Rome since November 2001. Vice President of the Conference of European Rabbis. Vice-president of the Italian National Bioethics Committee.